Well, as a kit someone could come up with some 3D printed parts so everyone could build one.
The same RPi that we use for TIPI (not the disk image itself, but the RPi hardware itself) could be used. We could simply burn RetroPie to the RPi microSD and install 99Sim and you now have the TI in a very small single board computer that you could easily connect via HDMI anywhere. Granted, you wouldn't have the expansion port but you would have pretty much everything else in a form factor you could fit in your front pocket (plus the ability to copy dsks/roms over your WiFi to the RPi). Wouldn't take long to build an image that we could download to a microSD and have it up and running in no time. Just a thought. It would be much more portable than using an existing TI gutted and re-mounted. You also wouldn't need an F18A or any other hardware. Speech would be emulated as would disks/CSx. As for TIPI, likely not unless it was something that the TIPI devs wanted to support in 99Sim (or other emulator).
If your intent is to use specialty cards, then this definitely wouldn't be an option. Otherwise, no reason not to (IMO). I'd be happy to make a How-To video if there is any interest?
Edited by jonecool, Fri Nov 9, 2018 12:03 AM.