There hasn't been much worth buying new for me in 2010 so far... but the last 3 months of the year are full of stuff I must have on day 1!
Dead Rising 2, F1 2010, Gran Turismo 5, Fallout New Vegas, CoD Black Ops, WRC Championship, Halo Reach, Fable 3, NFS Hot Pursuit...
Same as every year, all the good games seem to come out at the same time. Some of them may have to wait until Christmas.