It seems like partnering with someone like 4-Play would be the best way to achieve this without having to do rework on the design as it is an external unit that is HID compatible.
Now personally I would like to see a professional looking injection moulded case with the 4-Play integrated but that's not likely realistic with the lower production numbers we're talking about here.
Still, If this project can achieve a $200-300 price point and support all of the listed consoles (plus TG16 and NeoGeo) with HDMI output and SDCard Loading and have a decent looking case I'm all for it.