The Tandy/Radio Shack Color Computer can control the motor of the Cassette recorder. It could also switch the tape audio to the television speaker.
I remember some Disney titles that would show an image on the screen, play some audio, then load the next image.
The Intellivision Keyboard Component had an even more complicated setup. That system used all four track of a standard tape drive. One track for playing audio, another for recording audio, a third for outputting data and one for recording data.
There was a "Learn French" title the let you hear a person speak a word, then you would record yourself saying the same word, then it would replay what you spoke.