Hi rcamp48,   With your 4-wire cable you shouldn't do it, however there is a workaround if you have enough RAM or a PBI Hard Drive - you can use RAMDISK (or HDD). You should connect only one SIO device at a time (either PC with RespeQt or 1050). Copy stuff to RAMDISK/HDD, unplug SIO device, plug another SIO device and copy stuff from RAMDISK/HDD to the SIO device.   Or better buy 6 wire cable:   https://www.ebay.de/itm/6PIN-Original-FTDI-FT232RL-USB-to-TTL-RS232-Serial-Adapter-Cable-for-
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