Not exactly. NIB is a lossy format, and so is not particularly deterministic. There does not exist a software solution to reliably "bit copy" every possible copy protection scheme out there. Which is why so many games have crack screens on them... in order to be archived, most need to be cracked to remove the copy protection before they can be copied reliably.
NIB takes care of some of the lightest copy protection, but for the more sophisticated types, there is no general solution available. For Macintosh users, the Virtual ][ emulator comes with an ADT variant called A2V2, which can transfer NIB and another (so far) proprietary format for half-tracks. It'll work for some of your 2500, but not always. I have been working with Gerard Putter, author of Virtual ][ and A2V2 to incorporate the technology into ADTPro, but have been exploring other technologies as well to see if anything better can be engineered. So far, nothing.