Why is it you think the boards were made removable for the purpose of expansion? I would have assumed that removable boards were to facilitate troubleshooting & repair.
Although there are technical issues with interfacing foreign CPUs to the A8 bus, these would not have been insurmountable - the S100 bus was essentially the 8080 pinout, and there are certainly different CPUs available as S100 cards e.g. 68000, 8086, even the 6502. But the biggest issue I think would have been the chicken/egg issue of: an alternate CPU in the A8 would have no software available for it (apart from what the alternate CPU vendor provided), and without a significant install base, nobody would bother writing software for the alternate CPU, and without any good software available for an alternate CPU, nobody would want to buy the CPU board.